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The Relationship Between Arterial Blood Gases and Acid-Base Status with Outcomes in COVID-19 Patients Admitted to the Intensive Care Unit
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Fatemeh Rahmaanian   , Navid Kalani , Zhila Rahmanian * |
| Department of Internal Medicine, Jahrom University of Medical Sciences, Jahrom, Iran , dr.j.rahmanian@gmail.com |
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Abstract: (109 Views) |
Background and Aim: Monitoring acid-base balance through arterial blood gas (ABG) analysis is essential in COVID-19 patients. This study aimed to evaluate arterial blood gases and acid-base status and their association with clinical outcomes in COVID-19 patients admitted to the ICU.
Methods: This retrospective analytical study reviewed medical records of COVID-19 patients admitted to the ICU in Jahrom county during 2020-2021. Arterial blood gas values were collected over the first 10 days of ICU admission and analyzed using repeated measures ANOVA, adjusting for demographic characteristics.
Results: The study analyzed 296 COVID-19 ICU patients (mean age 64.4±17.4 years), revealing a 90.2% mortality rate (n=267) with only 9.8% (n=29) surviving to discharge. Deceased patients exhibited significantly lower pH levels (showing an increasing trend over time), higher PCO₂ levels (with a decreasing trend), and elevated LDH levels (demonstrating an increasing trend) compared to survivors. However, after adjusting for age, sex, and hospitalization duration, repeated measures ANOVA revealed no significant time-dependent effects, group × time interactions, or independent associations between these ABG/acid-base parameters and COVID-19 mortality in the ICU setting.
Conclusion: While deceased COVID-19 patients demonstrated lower pH and higher PCO₂/LDH levels compared to survivors, these parameters did not independently predict mortality in ICU-admitted COVID-19 patients. Further research is needed to fully elucidate the relationship between acid-base balance and COVID-19 outcomes. |
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| Keywords: COVID-19, Arterial blood gases, Acid-base balance, PCO₂, Intensive care unit |
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Full-Text [PDF 464 kb]
(17 Downloads)
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Type of Study: Original Article |
Subject:
Marine Medicine
Received: 2024/05/15 | Accepted: 2024/12/4 | Published: 2025/06/20
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