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Use of oncolytic bacteria and viruses: A new step in the treatment of lung cancer
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Seyed Kiarash Aghayan   , Hadi Esmaeili Gouvarchin Ghaleh , Reza Golmohammadi * |
| Baqiyatallah Research Center for Gastroenterology and Liver Diseases (BRCGL), Clinical Sciences Research Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran , golmohammadi27@yahoo.com |
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Abstract: (1 Views) |
In this study, the combined effects of oncolytic echovirus-6 and beneficial bacteria such as Lactobacillus casei and Bacillus coagulans, along with hyperthermia therapy, were evaluated on lung cancer cells (A549). The results showed that this combined approach not only significantly reduced the viability of cancer cells, but also led to a notable increase in apoptosis, production of reactive oxygen species, and lactate dehydrogenase release. Moreover, this combined method demonstrated better efficacy compared to single-agent and conventional drug treatments such as doxorubicin. The findings suggest that the combination of oncolytic echovirus-6 with beneficial bacteria, in conjunction with hyperthermia therapy, could serve as a novel and targeted approach for the treatment of lung cancer. Given its safety and specificity, this method can be considered as a complementary option alongside surgery, radiotherapy, and chemotherapy in lung cancer treatment programs. These findings may represent a significant step forward in the development of oncolytic microorganism-based therapies in the field of safe and targeted medicine.
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| Keywords: Lung cancer, Oncolytic bacteria, Oncolytic virus, Hyperthermia, Doxorubicin |
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Full-Text [PDF 306 kb]
(1 Downloads)
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Type of Study: Policy Brief |
Subject:
Marine Medicine
Received: 2026/01/8 | Accepted: 2026/01/26 | Published: 2026/01/30
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