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Development of Nanodrugs to Combat Treatment-Resistant Hospital-Acquired Infections
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Hamidreza Javadi   , Mohammad Tayebpour , Mohammad Hassan Darvishi * |
| Nanobiotechnology Research Center, Institute of New Health Technologies, Baqiyatallah University of Medical Sciences, Tehran, Iran , darvishi@alumnus.tums.ac.ir |
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Abstract: (1 Views) |
Treatment-resistant healthcare-associated infections (HAIs) represent a growing and multifaceted threat that poses serious challenges to global public health. The increasing prevalence of antimicrobial resistance (AMR) has not only reduced the effectiveness of existing antibiotics but has also created an urgent need for novel therapeutic strategies in clinical and hospital settings. In this context, medical nanotechnology, owing to its ability to engineer materials at the atomic and molecular scale, has emerged as a promising and transformative technology across various therapeutic domains. The potential of nanomedicines -either through targeted drug delivery systems or by introducing antimicrobial agents with novel mechanisms of action- plays a pivotal role in addressing this critical challenge. One of the most important reasons for the failure of conventional antibiotics in healthcare-associated infections is their inability to effectively combat protective bacterial biofilms. Nanoparticles, due to their capacity to penetrate biofilm structures and eradicate bacteria through physical and non-specific mechanisms of action, can bypass bacterial genetic resistance and provide a durable and sustainable therapeutic platform. This article reviews the most common treatment-resistant healthcare-associated infections, examines nanotechnology-based strategies to combat antimicrobial resistance, and proposes approaches for the development, regulation, and clinical implementation of nanomedicines in the management of HAIs.
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| Keywords: Nanomedicines, Healthcare-associated infections (HAIs), Antimicrobial resistance (AMR) |
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Full-Text [PDF 431 kb]
(1 Downloads)
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Type of Study: Policy Brief |
Subject:
Marine Medicine
Received: 2025/12/20 | Accepted: 2026/01/24 | Published: 2026/01/30
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