Methods and materials: 40 healthy overweight men were randomly divided into two groups: Functional training and control. The training protocol consisted of three sessions per week for eight weeks. Before and after supplementation and exercise, the variables of mir143, Glut4, insulin resistance and total antioxidant capacity were measured in all the subjects.

Results: The results showed that the mir143 and insulin resistance in the functional training group was significantly reduced compared to control groups. Also, Glut4 and total antioxidant capacity showed a significant increase in the functional training group compared to the control group.

Discussion and Conclusion: The results of this research provide convincing evidence for the beneficial effects of high-intensity functional training on mir143, GLUT4, insulin resistance, and total antioxidant capacity in overweight men. However, due to the limitations of the research, the need for more studies seems necessary.