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Application of Antibiotic-Loaded Sustained-Release Polymers in Controlling Postoperative and Combat Trauma Infections
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Ramzan Ali Taheri *   , Marzieh Dehghani , Hakimeh Nikzad |
| Nanobiotechnology Research Center, Institute of New Health Technologies, Baqiyatallah University of Medical Sciences, Tehran, Iran , taheri@bmsu.ac.ir |
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Abstract: (1 Views) |
Traumatic wound infections and surgical site infections (SSIs) are among the most common healthcare-associated infections. In particular, infections at sites of war-related trauma and surgical interventions in field hospitals present significant concerns. The location and type of surgery in injured personnel can contribute to severe complications or even mortality. Hospital-acquired infections often arise due to inadequate hygiene before, during, or after surgery, or prolonged hospital stays. Despite advances in infection control, including improved operating room ventilation, sterilization techniques, surgical methods, and antimicrobial prophylaxis, SSIs remain a major cause of postoperative complications, extended hospitalization, and death. In fact, most SSIs are preventable with appropriate strategies. One innovative approach involves the use of smart, sustained-release polymers containing antibiotics, such as in situ-forming injectable polymer implants. These systems offer the advantage of local drug delivery and can address the challenges of oral or injectable antibiotic administration during patient transfer from the battlefield to the hospital following initial medical interventions. This policy-focused summary examines the application of sustained-release polymers and in situ-forming implants in controlling postoperative infections, particularly in field hospitals on the battlefield. Postoperative infections can lead to serious complications, which are exacerbated in combat settings due to limited resources and infrastructure. Sustained-release polymers, as targeted drug delivery systems, and in situ-forming implants, as novel therapeutic strategies, can help reduce infection rates and improve recovery outcomes. This article reviews current evidence and analyzes the challenges associated with implementing these technologies in such critical environments.
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| Keywords: Infection control, Surgery, War-related trauma, Sustained-release polymers, In situ-forming implants |
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Full-Text [PDF 322 kb]
(1 Downloads)
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Type of Study: Policy Brief |
Subject:
Marine Medicine
Received: 2025/12/20 | Accepted: 2026/01/30 | Published: 2026/01/30
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