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Use of Chitosan-Moringa Biohydrogels with Sports Rehabilitation: A Policy Proposal to Improve the Speed of Complex Burn Healing
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Amirhossein Yadolahi   , Hamid Babavalian * |
| Applied Biotechnology Research Center, Institute of New Health Technologies, Baqiyatallah University of Medical Sciences, Tehran, Iran |
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Abstract: (4 Views) |
Full-thickness burn wounds, especially when infected with resistant pathogens such as Staphylococcus aureus, pose a major challenge in clinical treatment. These wounds significantly delay the healing process and increase medical costs. The current study investigated the synergistic effect of a biocompatible nanohydrogel based on polyvinyl alcohol-chitosan enriched with Moringa oleifera extract, in combination with high-intensity interval training (HIIT), on the acceleration of wound healing in a rat model. Rats were randomly divided into three groups: control, monotherapy (either the nanohydrogel or HIIT alone), and combination therapy. Healing indicators, including wound contraction, angiogenesis, epithelialization, and collagen deposition, were evaluated on days7,14, and21 post-intervention. Results showed that the combination therapy group exhibited the fastest and most complete wound healing process. This group outperformed the others in terms of wound contraction, angiogenesis, and organized collagen deposition. The integration of the active nanohydrogel with HIIT, as an innovative approach, not only enhances the speed of healing but also improves the quality of tissue regeneration. This strategy has the potential to reduce treatment duration and alleviate the economic burden on the healthcare system. Such a combination could serve as a novel option for the management of complex wounds.
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| Keywords: Skin Burn, Biopolymer hydrogel, Chitosan-moringa, Exercise |
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Full-Text [PDF 320 kb]
(3 Downloads)
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Type of Study: Policy Brief |
Subject:
Marine Medicine
Received: 2026/01/7 | Accepted: 2026/01/30 | Published: 2026/01/30
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