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:: Volume 2, Issue 1 (Spring 2020) ::
J Mar Med 2020, 2(1): 33-40 Back to browse issues page
ACE-2; an Entry Receptor for SARS-CoV-2
Maryam Saeidi , Mahshad Kalantari , Ehsan Dordizadeh Basirabad , Maliheh Entezari *
Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran , medicine.med2000@yahoo.com
Abstract:   (6817 Views)
The new coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes an infectious disease called coronavirus disease 19 (COVID-19). This disease is highly contagious, and it damages organs due to the high affinity of Spike protein for the human angiotensin-converting enzyme 2 (ACE2) cell receptor, which is highly expresses in organs such as the lungs, heart, liver, kidneys, brain, and bladder. These organs seems a probable host for the virus although the main target tissue of the virus is the lungs. In general, the virus enters the host cell by Spike protein, which it is a good candidate for the vaccine design. Inhibition or blockade of ACE2 receptors using antibodies that neutralize this receptor can be a hope to prevent the virus from invading the cell and causing damage.
Keywords: Angiotensin-Converting Enzyme 2 (ACE2), COVID-19, Coronavirus Receptor, SARS-CoV-2
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Type of Study: Mini Review | Subject: Marine Medicine
Received: 2020/06/29 | Accepted: 2020/07/19 | Published: 2020/07/19
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Saeidi M, Kalantari M, Dordizadeh Basirabad E, Entezari M. ACE-2; an Entry Receptor for SARS-CoV-2. J Mar Med. 2020; 2 (1) :33-40
URL: http://jmarmed.ir/article-1-83-en.html

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Volume 2, Issue 1 (Spring 2020) Back to browse issues page
مجله طب دریا Journal of Marine Medicine
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