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Evaluation of the effects of alcoholic and aqueous extracts of the root of the tangress plant (Amygdalus lycioides Spach var. horrida) on prostate cancer treatment
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Mitra Arman   , Hossein Amini Zadeh , Mostafa Alinaghizadeh , Mojtaba Naderi , Hosein Jaferi , Saeid Tamadoni Jahromi * |
| Persian Gulf and Oman Sea Ecology Research Center, Iranian Fisheries Sciences Research Institute, Agricultural Research Education and Extension Organization (AREEO), Bandar Abbas, Iran & - , stamadoni@gmail.com |
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Abstract: (582 Views) |
Background and Aim: Prostate cancer, after lung cancer, is the second most common cancer in men worldwide and the second most common cancer in Iranian men after stomach cancer. To control this disease, methods with minimal side effects are of particular importance. One such method is the use of medicinal compounds found in natural resources such as medicinal plants. This study aimed to evaluate the effects of methanolic and aqueous extracts of the root of the Tangress plant on prostate cancer cells.
Methods: In this study, the cytotoxic effects of the methanolic and aqueous extracts of the Tangress root were investigated on prostate cancer cell lines (PC3) at concentrations of 1000, 500, 250, 125, 62.5, 31.25, and 15.6 (µg/ml) over 48 hours. The IC50 values of the extracts were determined, and statistical analysis was performed using a two-way ANOVA and independent t-test.
Results: The results showed that both extracts significantly reduced cell viability. The IC50 values for the methanolic and aqueous extracts were 184.8 and 148.8 µg/ml, respectively. The two-way ANOVA test showed that the different concentrations of both extracts significantly differed from the control group (P<0.05). Additionally, the t-test between the two extracts showed no significant difference between their IC50 values.
Conclusion: The findings of this study suggest that both methanolic and aqueous extracts of the Tangress plant root have a considerable inhibitory effect on prostate cancer cells. Given the lack of a significant difference between the effects of the two extracts, both could be potential candidates for further research in prostate cancer treatment.
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| Keywords: Tangress plant, Aqueous extract, Methanolic extract, Prostate cancer. |
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Full-Text [PDF 476 kb]
(167 Downloads)
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Type of Study: Original Article |
Subject:
Marine Medicine
Received: 2024/06/7 | Accepted: 2025/03/1 | Published: 2025/02/28
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