In late December 2019, SARS-CoV-2 caused the outbreak of pneumonia, COVID-19, in Wuhan, China. COVID-19 is still a major health threat worldwide and has claimed many lives. It has infected about 220 countries, including Iran. According to world statistics, its fatality rate is 4.3-5.3%. The virus is classified on the Virus Classification Committee as Severe Acute Respiratory Syndrome. The early symptoms of COVID-19 include: pneumonia, fever, muscle aches and fatigue. To date, unfortunately, there are no approved vaccines or antiviral drugs to control this infection. Therefore, prevention, infection control, and compliance with health principles are still a top priority for people. People with this infection develop significant respiratory problems from pneumonia, and consequently symptoms such as decreased oxygen levels, shortness of breath, irritable and dry cough, pharyngeal irritation, sputum, and risk of pulmonary fibrosis. The purpose of this review is to evaluate the role of respiratory physiotherapy in the treatment of patients with COVID-19 based on available evidence.